Roland Faure

Roland Faure

I am a recently graduated PhD student working on sequence bioinformatics. I like imagining and implementing algorithmic solutions for biological problems. During my Ph.D., I focused on genome assembly, more specifically the problems of haplotyping and metagenome assembly. For my postdoc, I am implementing efficient methods to browse through the Logan dataset.

// ABOUT ME

My research lies at the intersection of biology and computer science, with a focus on developing algorithms for large-scale genomic data analysis. Since February 2025, I am a postdoctoral researcher in Rayan Chikhi's group at Institut Pasteur, Paris, working on efficient indexing and exploration of the Logan dataset. Previously, I completed my Ph.D. (2021–2024) on metagenome assembly under the joint supervision of Dominique Lavenier (Inria Rennes) and Jean-François Flot (Université Libre de Bruxelles).

// PUBLICATIONS & PREPRINTS

    First author

  • R. Faure et al. Alice: fast and haplotype-aware assembly of high-fidelity reads based on MSR sketching, Preprint (2025), [PDF] [link]
  • R. Faure et al. Hairsplitter: Separating noisy long reads into an unknown number of haplotypes, Peer Community Journal (2024), [PDF] [link]
  • R. Faure et al. strainMiner: Combining Integer Programming and Data Mining Techniques for Strain-level Metagenome Assembly, BIOSTEC/BIOINFORMATICS 2024, [PDF]
  • R. Faure et al. QuickDeconvolution: fast and scalable deconvolution of linked-read sequencing data, Bioinformatics advances (2022), [PDF] [link]
  • R. Faure et al. GraphUnzip: Untangling assembly graphs to finish assemblies, [JOBIM 2023] [Ph.D. chapter (2024)]

  • Ph.D. thesis

  • R. Faure Haplotype assembly from long reads, (2024), [PDF]

  • Contributing author

  • R. Chikhi et al. Logan: Planetary-Scale Genome Assembly Surveys Life’s Diversity, Preprint (2025), [PDF] [link]
  • O. De Thier et al. First chromosome-level genome assembly of the colonial chordate model Botryllus schlosseri (Tunicata), GigaScience (2025), [PDF] [link]
  • A. Choudhury et al. Deep mutational scanning reveals the molecular determinants of RNA polymerase-mediated adaptation and tradeoffs, Nature Communications (2023), [PDF] [link]

// CONFERENCE TALKS & PRESENTATIONS

Logan project

MSR sketching & Alice assembler

HairSplitter: distinguishing errors and variants in long reads

GraphUnzip: combining Hi-C with assembly graphs

  • SeqBIM 2021 [slides]
  • JOBIM 2021

Ph.D. defenses

  • Rennes 2024 (official defense) [slides]
  • Brussels 2024 (unofficial defense) [slides]

// SOFTWARE

Alice

HiFi metagenomic assembler. Its originality is to introduce and use MSR sketching, which allows the assembler to assembler reduced sketches rather than original reads while distinguishing strains

HairSplitter

Maps long reads to an assembly, detects regions where haplotypes are collapsed, groups reads by haplotype, and reassembles each group separately. Yields an assembly where all haplotypes are separated.

Strainminer

Same software as HairSplitter, with the core algorithm reformulated as an ILP problem solved with Gurobi (experimental).

GenomeTailor

Correct an assembly graph by realigning long reads on it.

GraphUnzip

Uses long reads and/or Hi-C to improve the contiguity of assembly graphs.

QuickDeconvolution

Scalable solution for barcode deconvolution of 10x reads.

// CAREER

Postdoc

2025-?

Browsing the SRA - Institut Pasteur

Working with Rayan Chikhi on searching efficiently through the Logan database to create a "super-BLAST" for the full SRA.

// EDUCATION

Ph.D. in Bioinformatics

2021-2024

Haplotype assembly from long reads

Joint supervision between Dominique Lavenier (Inria Rennes) and Jean-François Flot (Université Libre de Bruxelles). Developed HairSplitter and Alice assembler.

Master in Bioinformatics & Modeling

2020-2021

Sorbonne Universités, Paris

Engineering Degree

2017-2020

École Polytechnique, Saclay

// TEACHING EXPERIENCE

Java Programming

2021-2022 20h×2 practical sessions for 1st year bachelor computer science students, University of Rennes.

Python Object-Oriented Programming

2022-2023 34h×2 practical sessions for 1st year master bioinformatics students, University of Rennes.

Bioinformatics Crash Course

2022,2023,2024 6-hour crash course for high-school students selected for the International Biology Olympiad, Brussels.

// STUDENTS SUPERVISED

Tam Minh Khac Truong

2022-2023

StrainMiner: ILP for strain separation in metagenomes

Two master internships (4+6 months). Best student paper award at BIOSTEC 2024.

Olivier De Thier

2023

Improving ascidian genome assemblies with long reads

6-month master thesis producing high-quality genomes for Botryllus schlosseri and Polyandrocarpa zorritensis.

Baptiste Hilaire

2023

Sequence reduction for bioinformatic tools

6-week bachelor internship exploring Mapping-friendly Sequence Reductions (MSRs).

// REVIEW ACTIVITIES

Conference Reviews

ISMB/ECCB 2024, Recomb-SEQ 2024

Journal Reviews

NAR Genomics and Bioinformatics (2022), Bioinformatics advances (2024), PCI Mathematical and Computational biology (2025)

// CONTACT INFORMATION